Speaker
Ana B. Caballero
(Universitat de Barcelona)
Description
Conformational pathologies, including neurodegenerative ones, are characterized by misfolded proteins called amyloids, which lose their physiological role and acquire toxicity. The accumulation and spread of amyloids is related to an impaired proteostasis network. Chaperones, as key actors of proteostasis, have thus become promising drug targets and models.
We are exploring how metal nanoparticles might be used to either emulate or assist natural chaperones' action against amyloid accumulation in Alzheimer’s disease.
Primary author
Ana B. Caballero
(Universitat de Barcelona)
Co-authors
Prof.
Patrick Gamez
(Universitat de Barcelona)
Dr
Raimon Sabaté
(Universitat de Barcelona)
